Oh god yes.
The timeframe that has always fascinated me are the the years after the settlement by the Andals (and the Rhoynar) but before the arrivals of those pesky purple eyed freaks (jk some of them were cool-I'm looking at you Aemon and Jahaerys).
 The possibilities are virtually limitless as little is concrete about this massive era giving us tons of room to experiment.

Just my two pennies.