I think what you're suggesting is a pretty cool concept, but I also believe it's been done to death. I don't know how much of a fantasy/magic aspect you need in here, but maybe consider that, I dunno, the teens were taken by human traffickers to be a "test group" for a new medical procedure or something. It'd be totally rad if these kids were, like, paralyzed and missing limbs but still kicked bevies of ass all over the place.

IDK though that's just me throwing ideas at you. I'm totally up for this either way, but you'll have to specify exactly how wordy you want the RP to be since I'm a high Casual, low Advanced, multi-para kind of player normally, so this is a little out of my comfort zone.