The Anti-Hygrons are pretty interesting and I can tell you have put some weaknesses into their fighting styles to make things tough but fair. From what I can tell the best way to deal with them would be two  fighters who work well together vs  Annabelle and Frederick preferably one defender and the other a hard hitter, a close range fighter to handle Takashi, either a long rage fighter or an unpredictable one would be the best to handle Simon, Riku would hate to fight someone either fast enough to dodge him or someone who could out think him, if he can control Drew´s bullets Nick would give him a lot of trouble and Zeke would probably have even more trouble with a counter fighter then Riku.