Would it be possible to take a pre-existing Sasanian house and play it, but with a mixture of fictional and historical characters?

I was thinking about using the House of Karen, one of the Seven Parthian Clans, an aristocratic family from Gorgan who had their seat at Nahavand, which would be somewhere either in the NPC area or Media I think (hard to tell in comparing the maps; near Hamadan in modern-day Iran). Anyway, they were relatively prominent in the Sasanian political and social hierarchy---Sukhra, one member of the house, had even been the [i]de facto[/i] ruler of the empire for a little while during the 5th century (he was basically the Dick Cheney of the Sassanid Empire), and Bozorgmehr, one of his sons, was the Grand Vizier during the reign of Khosrau I. In addition, there are a number of historical spahbeds ("army chiefs") that are listed that fall within our time period---I was thinking that I could adapt some of those personages from history while filling in the rest with my own imagination. I think that using such a a prominent family would be a perfect way to illustrate Sasanian social and military traditions, and the House of Karen certainly played a role in the defense against the Arabs. 

Thoughts? Or would you rather have an OC house? 

Also, what year will we be starting in, or has that been decided yet?