I've literally spent 5 hours, just going on runs over and over again to actually get something good in the first item room. The D6 for Isaac didn't help at all and I literally refuse to try any other character because I just unlocked the D6 for Isaac through a grueling and painful run with blue baby. I want to exhaust it and revel in its power but its just not giving it to me

*silent crying in a corner*

Well, enough with that... What about you guys? What are some of your painful experiences with the game?