Absolutely love BoI and on most runs I can usually get through to the Chest or the dark room with ease. Still haven't done hard mode but that's due to the unlocks that I still wanna get for Samson and Cain.

My best run was a first room brimstone with heaps of tears up and I became guppy. The power was absolutely insane! Worse I can remember was taking 9 lives then accidentally going into a cursed room. Imagine being forced to kill yourself 9 times because that's your only option. Gaaah lol.