I've taken to describing what Isaac (or whomever he's pretending to be during a run) aloud after collecting some items after a while.

'So, I originally only had one eye, and the other was covered with an eyepatch. But then I got a blood clot, so my eyepatch is covered in a blood clot.  And I stabbed myself with a wire coat hanger, so I cry a lot more. I just drank some rancid milk, but I then made a pact with the devil, so I got a nice cloak which makes me look like a sith from star wars.'

Next, I'm going to start composing haikus.