[quote=@Savato]
That's a resistance, if you influence the effects in a way that don't affect you as much as the average char. Doesn't have to be broken Apocalypse levels. 

Name one thing toons can't actually do. Or at least a situation where their abilities can't bail them out (except soul extraction, because that was imposed) effortlessly. o;
[/quote]

Being tied up. Being caught in a net. And injuries can put them down for a little while, esp since they take extra damage. But otherwise not that much. Plus they mostly have notable personality quirks that are easy to take care of.

I mean, while looking for Toon weaknesses, I came across a Disney MMO back in the early 00's named Toontown where a toon couldn't do much if they were saddened. So I could try to work that. Can't kill a toon, but makes them unable to fight for awhile.