I'm thinking of running a RP based on White Wolf's Hunter the Reckoning. 

To the uninitiated, the basic premise is that a small number of people have awakened to the the existence of supernatural creatures that hide in the shadows and prey on humanity. Upon their awakening these individuals are bestowed with extraordinary powers that help them confront the monsters. However even these powers do not make Hunters invincible. Most die when they underestimate an opponent and rely on popular culture for their understanding of supernatural. Others find themselves behind the bars, on the run or in hiding, because the most powerful creatures pull the strings of police and government agencies. Yet others are driven insane by post traumatic stress, loss of friends and loved ones.

The RP will focus on adventures of the group of newly awakened Hunters, with a possibility of couple supernatural characters.