I personally hate repetitive questions. Prime example: "What's up?" 

The same question from the same person, day after day and maybe even MORE frequently than that.

Despite what narcissistic self-help gurus tell you, not every day is a new adventure. Most days experienced by people are fairly mundane and do not change in any significant manner. 

I understand that such a phrase is an ice breaker, something to get into actual conversation, but it only works so many times before it becomes grating. At the very least rephrase the question every once in a while.

Aside from that, the question is so...vague. What's up? I dunno, do you want a total retelling of my experiences from the past day? Highlights? Or are you literally inquiring about the content of the space above us?