[@Ophidian]Well, understanding concepts from physics or at least the layman explanations of them shouldn't require any math skills, rest easy.
As for vacuum energy missiles they can be your rarely used doomsday warheads. I mean with sufficient butchering of physics you can say that vacuum energy generation creates unstable exotic particles which might have effects so harmful it makes radiation fallout look like Disneyland.

As for tech how about having a "vacuum cell" in the warhead with finely controlled environment to momentarily harness this power into a massively powerful explosive device? They would be also fail-safe because it requires a specific activation and thus it won't blow up your ship upon damage or destruction.