Well, let's try to remember this is absurd anime ideas. If your idea has been done to 95% completion before, it probably isn't that absurd... I mean within the context of anime. Bobobo-bo Bo-bobo is an anime after all, so absurd things do happen. Still, finding an original idea is pretty challenging!

Okay, how about an anime where the characters are all girls but, BUT... they are ugly. And by ugly I don't mean that they are ugly, just that they have non-standard body types. Like maybe one girl would be flat chested but have a big butt. Another one might have a skinny neck and buck teeth, etc. They meet up at a local laundromat and talk frequently about their boy woes and how they are picked on by their friends and co-workers. The guy who runs the laundromat is a foriener, so the girls take a shining to him and visa versa. I'm not sure if it's magical or mechanical, but each girl eventually gets awashing machine or dryer that does something strange when you climb inside it. One has the power to turn into vehicles, another one can become a portal to any other place with a round opening (other washer/dryer, sewer drain, bucket of water) etc. They are all color coded like power rangers. The villains are all super attractive yet vain characters who view beauty as the single most important attribute one can possess.