[@Spriggs27]
Realistically the first person to go would be good ol' blind bertha. Afterall she'd never see it coming.

Kara has many possible ending routes to go down

Despair End: Losing all hope, Kara falls endlessly into the loving embrace of despair, bringing despair wherever she goes. Despair to the past, despair to the present and despair to tomorrow.
or
Chiaki End: Is everyones hope and friend, dies cruely at the hand of bad luck

But I also think it'd be more, she gets filled with hope but is crushed with despair due to the deaths and executions of her friends. Possibly suicides el ogre style. Or maybe she finds herself madly in love with despair as an admierer of Junkos' work. Building hope up in herself only to transform it into a flame of burning despair.