[quote=@Rithy]
[@Dervish]

You'd think Mass Effect villains never learned :P

Saren: "Oh no, Shepard is gaining on me! What do I do? *Frantically shoots multiple civilians*... wait, I should totally just get myself some Reaper IMPLANTS! What's the worst that could happen to my free will?"
Illusive Man: "Oh no, Shepard is gaining on me! What do I do?" *Frantically blows multiple cigarettes* ... wait, I should totally just get myself some Reaper IMPLANTS! What's the worst that could happen to my free will?"
[/quote]

TIM was indoctrinated a long time ago (sometime around 2158; ME2 takes place in 2186), I know for a fact TIM was indoctrinated back just after the First Contact War on Palaven when Saren's brother discovered a Reaper Monolith. 

Saren is trickier to pin down, but he came into contact with Sovereign prior to the events of ME1.

Regardless, in both cases, both individuals are well under the Reapers' thumb by the time you encounter them in game.