[@Natsu]
Well, not exactly. You’d certain put people at a disadvantage tactically by separating them, as Familiars need to willingly give up their mana to a Mage, which they can only do with the Mage is nearby. And the emotional bonds aren’t quite that destabilizing. Separation anxiety doesn’t work that way at all. If this hypothetical situation did happen to a pair that had strong empathy and separation anxiety, they would definitely feel more anxious, bothered, tense, and upset without their partner. But driven insane? Probably not. Rather, the circumstances of being kidnapped would ultimately prove more damaging than being separated from your partner.

With that being said, Natsu, please do not engage in kidnapping and nazi-esque experiments in torture, it’s very rude and rather unbecoming. :P