I like Deadpool a lot. Though most of my favs are Marvel heroes because DC heroes are too... whats the word... Overshadowed and ruined by the mere presence of Superman? 

For villains. Marvel Dr. Doom is pretty good and will make a great return when Fox finally gives up the Fantastic 4 license. DC, probably the Joker or Lex. DCAU made sure of that.

Superhero stories are more comedy than serious broody stuff anyway. Because they aren't ever allowed to be 'serious' if they go broody, otherwise Joker would dissolve everyone, Batman/Tony would destroy everyone with nanobots, and it would be a big mess.