[quote=@spiral origin]
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It's damage prevention. Damage is discerned by its attempt to change something about Noxie in a way that is detrimental or disruptive. That might also result in effects that have both a positive and a negative effect being negated, however Noxie is able to allow a positive effect to take place while barring the negative if he wills it. It does apply to non-physical attacks of all types--anything that attempts to change the structure/chemistry/essence/form/etc of any part of Noxie, physical or otherwise, is negated. I think I will change the ability name to "Immutable", that seems more fitting. Basically, Noxie cannot be altered in any way.
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Usually any ability that trumps every other ability (for instance, One Punch Man defeating anything in a single punch) is bound by the user's home dimension. Existence is full of so many varied powers that beating them all with your own is unlikely.