[quote=@GubGar]
Question; I was considering adding a villain or two of this universe into my Spider Totem's backstory, and wanted to see if that'd be alright. If any are off limits that's totally fine, I was considering Mac Gargan and [i]maybe[/i] Kraven.

[/quote]

Both of those are good to use. The only one that's really off-limits is the Green Goblin since he doesn't exist yet, but the Hobgoblin does. He was Caty's first villain.

Caty and Danny took on Mysterio so he exists as well and there may have been a symbiote Danny event. Black Cat exists as well, but genderbent so [@Polaris North] may have had a run-in with him.

Your characters may have vague memories of Doc Ock being a villain, but you wouldn't really remember until you started traveling through the multiverse.