Nothing would withstand a blackhole within the Event Horizon, because the molecular structures are shaken and pulled so much they just fall apart. Theoretically, anything that passes into the Event Horizon would instantly be turned into... well, tiny individual protons and neutrons and electrons. There would be, theoretically, nothing left whatsoever. A true black hole would have this power; a synthesizer would probably have the properties of a black hole, but again, a black hole is just something that became so incredibly dense that it created a gravity field that just grew and grew, until it collapsed in on itself. A synthesizer would probably be able to crush and munch stuff up, and maybe shake up weaker, less-bonded molecular structures, but high-density stuff would probably be tough enough to withstand until it got out of range.