I had a problem with Diablo 2, since it was too old for my comp. In full screen, it had these odd fucking colors throughout the entire screen, and it was just all around screwed.

Right click on the shortcut, go to Properties, Shortcut- Target- Add '-w' without the ' to the end.

What is does is gives you a smaller screen to play by. It cleared up Diablo for me. Might work for you. There might be a space between the .exe and the -w. If neither of those work, I tried.