Do you mean a transgendered character? 

We're LBGT friendly in this group, so I doubt anyone would mind. You can PM me your ideas and CS if you are unsure about sharing it until you've got it all fleshed out.

I don't have any experience with that personally, or wrote about it(yet), but I've wrote for a lot of other types of characters I have no personal experience with and it all worked out. Researching can be fun.