I'm definitely thinking about the intelligent SuperMutant thing. In the NV area, where would they come from, how would they get away, and what repercussions would they face from where they came from for leaving? Bit of lore that I'm shy on.
Same questions would go for the Ghoul idea as well....so if both sets of questions could be answered, I can better make the decision as to what character I'll be making :)