The Flash has the Speed Force, though, which actively works to prevent all of the negative side-effects of superspeed.

I'm not trying to argue, I'm just pointing out that your references don't exactly work in this case due to things like The Flash coming from a setting with a [i]far[/i] softer approach to science. Whilst this is still somewhat soft, the OP [i]did[/i] say things should be played realistically.