[quote=Archmage MC]
To be fair, if Superboy prime doesn't have vital organ regeneration, all you need to do is make a bunch of nanobot bombs and have him inhale them, which is pretty easy if they're tied to a gas grenade. Add in some kryptonite in those nanobots for even better results.He was silver ages, way before nanotech was a thing, nowadays hes not that big of a threat.
[/quote]

No such luck Mage, for a couple reasons. First off telescopic sight. He's see those suckers coming a mile off. Secondly super-speed, he ain't ever gonna get caught in a gas cloud if he didn't want to, and even if he did he can hold his breath indefinitely. Finally Superboy Prime has no weakness to Kryptonite, or magic for that matter. He felt the effects of K-Rad once, but that has since been retconned out. 

He does have weaknesses though, primarily red sun radiation which saps his strength. He also fears speedsters and the dark, but those would be hard to utilise.