Come on Sleeth and engage that super charged synapses system of yours

Too bad Penny isn't in love with someone then that would be easy leverage.
Bribes......hmmm; that would just be another demonstration of attention.

Hmmm............ Ignore her?
Difficult but she'd be forced to engage more and more of her creativity till she might reach her limit or give the observers something new each day to study.
I mean think of the level of IQ she's already shown and she's not even in the smart group.
Who knows exposure to the others might level her out or she might form friendships, hell as much as she was toying with Liz she was actually being nice at the same time. Heck she even told Liz she had balls an not to sell herself short.

If this Girl could be slowly tamed and brought to see that the Administrators had nothing to do with the loss of her parents and were even a bit sympathic to her then Penny would (pardon the pun) shine.

Now of course she'd need to be watched like a hawk or she will escape, no she'll eventually escape anyway.

Bring her in and knock her out then install a short range internal tracker in her that would help retrieve her when she does escape. But it'll need to look like a normal procedure

We could simulate the effects of appendicitis which would explain the incision..