Well, things got difficult. Also Permanent Stat Drain. 

Definitely a thing (Ren has lost 9 Stat points herself). Things that specialize in that are demons, Necromancers, and other 'dark' powers or beings in general. (generally it happens if you Fumble while resisting some things, but others can actually do it without a fumble)

Also for killing the Spatial Mage, the Gamers got some XP (not enough to level up, but some), but now she's back. 

They could get XP by killing her again, but right now I think killing the guy who ressurrected her is probably a better idea XD