I've got more than a few concepts for you. They each would come with their own starting point as a setting, some with a more detailed backstory, but none of them impossible to move into territory completely foreign to them right from the start. :) And none of them without the possibility of tweaking either. One or two could even fit with the first setting offered by Wernher if Wernher is amenable to a second player getting in on the action. :) 

Thought I'd check first though, I noticed you mentioned having more than one person in a thread, but not sure if you're looking for more than one possible thread? 
Soooo, are you looking for more than one potential plotline/thread/rp?

Didn't want to rattle off a list when I might be rattling for no reason.