So, wait.... If the stake in the heart halts his regenerative abilities... Then twisting it would kill him? I mean, it ain't pumpin blood, oxygen flow stops within 7 seconds, blood stops flowing immediately, I mean, a stake is pretty big, it's crush at least two chambers just by being there. All you'd have to do to destroy the rest of it it just, twist it a little bit, or even like a blender, just the force to turn a doorknob would sever the arteries and veins, crush the remaining chambers, and basically deflate it like a sad, little heart balloon.

Not that I'm an expert of staking people... Or crushing hearts.... Except for that one time in freshman year... Sorry Samuel....