[quote=The Whacko]
I'm up for that if you are. Maybe there could be a sort of re-emergent Confederacy? Sort of the region's own NCR.
[/quote]

Now [i][b]that's[/i][/b] an idea, my friend!
An idea of mine was to basically have a faction derived from a Vault that originally was reserved for military personnel only. Many of humanity's most advanced war technology was stored here for protection, and for many years the people their solely focused on R&D and the protection of what they had. Only recently have they started exploring. They could replace BoS.