Well it gets easier when you try and use what your character is good at against them. Your character may be smart as hell, but is so intelligent to the point that she rarely seriously consider that she might be god forbid wrong about something lol. 

Physical weaknesses are the same thing. You can be very athletic and have a great deal of stamina. However you lack the ability to summon bursts of strength to over most opponents easily. Its still annoying to try and do it. At least it prevents you from making a perfect character which is boring.