Many years ago, the world plummeted. Nobody knew who started it, but we have ceased to care. All that matters is that the world was plunged into chaos. Nuclear missiles launched from every country that had them, nobody was safe. This went on for years, even after the missiles exploded. Then it happened.

First it was one person, then another, then there was a rather large explosion of people who had abilities never seen before. Science couldn't explain how they worked, but people didn't seem to care. All they knew is that people were becoming superhumans, with spiritual and scientific abilities that surpassed our understanding of science. 

After the war, the earth became deathly silent, trying to salvage any remains of civilization and recreate the world. With the help of the Abnormals, as the superhumans were called, it made rebuilding easier, but also more difficult. Eventually, Sanctuary was built in the ruins of Washington DC, a new city with walls as high as buildings, making sure that people couldn't get in or out. A new guard force was created to protect Sanctuary, consisting of any able-bodied people within the walls.

The Leader of Sanctuary is known as The Mother, who was one of the first Abnormals to be created. She had many abilities at her disposal, and her longevity and vitality kept her from aging as quickly as normal people. She created pure water for the people of Sanctuary, among many other things.

There had been many times in the past where Sanctuary has been attacked, and all of those times, The Mother was able to help the people of her city by siding with the patrol, but these days she had grown old, and cannot fight and protect like she used to. Now, the people of Sanctuary need to find the next Mother, so that they may protect the city from natural dangers and other humans out in the red waste. Their time is short, and the supplies are limited.