First off this is still set in San Francisco, San Fransokyo is replacing Oakland.

But yeah I think it would be super tough to do without a spoiler tag which this site doesn't have.... or being almost too super vague.

I would love the idea though (just bought a Hiro Hamada pop figure to boot). Could also look into the Marvel comics version to mix it up enough from the movie. But I don't know much about the comic version.