Isa was frantic and off balance but she was a master fighter, although she couldn't adequately defend herself in such a short amout of time, she knew it was coming and her instincts kicked in, although she was temporarily blinded, she always kept her chin tucked in as part of her experience in boxing and did so the moment the liquid hit her, with the force of a haymayker she was cold clocked with the glass that the man was holding, he was probably aiming for the lower part of her face, but because of her last minuite chin tuck the base smacked against her much harder forehead. 

The impact was staggering but not unbearable the glass smashed and the first broked shard made a moderately cut right above her eyebrow and a a few of the smaller fragments cut  her right ear. But there was an advantage, because of her bullheaded forehead charging stance she resisted any knockback from the dirty attack and was now ready to counter as she started to feel blood drip over her eyebrow.

Like a springboard while the large mans hand was still extended she sliped forward at a very slight angle and threw a quick but stiff jab-straight combo to the exposed body underneath the targets armpit, she would then use the angle to circle away to that same direction to hopefully create some space.