Makes plenty of sense. Essentially the RP will open shortly after the aftermath of a clan dispute that had the players fighting one another (abstracted away of course). The fighting was interrupted by the sudden arrival of some very well-equipped vampire hunters, you and your fellow RPers fill the role of those they managed to capture alive. Once abducted your hearts were carefully extracted (Yes, even what passes for a Vetala's heart) and are currently being held hostage. As this means they can snuff any of you out at their leisure (by destroying these hearts you're likely to never see again) you've been left with little choice but to do their bidding.

The plot is more of a guideline. There are certain things that will be happening simultaneously in the background whether characters become aware of them or not (So be crafty!) and I whole-heartedly encourage players to play against the narrative. It won't end well for anyone if you simply docilely accept commands. 

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On an unrelated note I nearly forgot to mention the key advantage of being a flimsy Dhampir. They're the only vampires compatible with cybernetics.