Yes help would actually be appreciated now as for what I have at the moment.

For the Demon Blades here are a few things to narrow it down some.

1. As I mentioned a somewhat fantasy style, historical Japanese setting with all the trappings.  Perhaps demon blade wielders could be hired by the local Shogun for various enterprises.  Or could just get caught up in the flow of events happening around us, but I think being connected to the Shogun would make it easier to give the group drive and purpose.

2. Demon Blades I think should only give 1 to 2 abilities max.  These abilities can either be some kind of enhancement like super strength or a usable technique of some kind.

3. Probably human only player characters, that way any special abilities come only from the demon blades.

Now for the Escaped Experiments Roleplay.

1. The experiments can be pretty eccentric and unique, with various abilities at their use.

2. The agents and creatures sent after the experiments will be constantly changing tactics and forms so you'll have to adapt to each threat or be captured.

3. The mad scientist will not be a slouch in combat but like a good many villains likes to use other means to accomplish their goals.  Besides they will get some good data as they send different creatures after the experiments.