As far as mundane society goes I'm working on a pessimistic take on many of FutureTimeline.net's predictions, with the main focus being that:
Humanity has [u]not[/u] curbed its appetites in the face of radical climate change and ecological damage
Humanity [u]refuses[/u] to enter into a more enlightened age, with individual lives being valued less than ever before
Humanity's reach has [u]exceeded[/u] its grasp as a technological bloat fans the flames of consumerism

*Designer babies for the wealthy meaning that the division between rich and poor has never been as great as it is now. It's full blown Gattica in this regard, with naturals feeling the crunch of a glass ceiling that drops a few inches every year.

*While there's no 'silver-bullet' for aging the key factors at work have been identified. With major advances in the use of stem cells, gene therapy, nanotechnology and other techniques a so-called actuarial escape velocity has been reached where the wealthy can extend their live by more than twelve months every year. (For all intents and purposes getting younger each year.) This means that the highest paying, most desirable positions in society never become available for the newer generation outside of accidental death or injury, as one can imagine this had made the business world all the more cut-throat.

*The US has collapsed under the weight of its national deficit and a 'death by a thousand cuts' brand of cyberterrorism. During this period of depression Canada stepped in to provide international aid. The growing concern is that Canada seems unwilling to 'step-out', policing the former super-power by way of naturalized refugees the U.S. had been unwilling to open their borders to years prior.