[quote=@Elitestpotato]
Question. What is the timeline we are going off of here? Did the Lone Wanderer poison the water supply or purify it? What of all the smaller choices you make in game? Is Megaton still there or did the Lone Wanderer blow it up? What of the Courier? Which side did he/she choose? What of the groups the Courier affected? 
[/quote]

On the New Vegas side of canon, it appears the RP is running off the NCR ending, and the Mojave Brotherhood of Steel has been convinced to peaceably leave the West Coast and regroup with the outlier group (the ones who wanted to interact with Wastelanders instead of just taking any technology they can find) they sent out east circa Fallout Tactics.