[quote=@Dinh AaronMk]
So once you get to that scale it's plausible that things may be so far beyond our scope of imagening (SP?) that society or species would have evolved beyond what we know. It could be far too abstract for us to tackle, and I tried to do that once, but I couldn't wrap my head around the necessary functions to explain it, even as a fictional mechanization.
[/quote]

Hmm. Is it necessarily so post-singularity god being, or simply a bigger swarm of drones?  After all, it's easy to imagine a massive multi-galactic civilization of self-replicating probes that has spread across hundreds of galaxies.  It's just hard to figure out what to do with them.  Like, the mongols I don't really consider that advanced (they just had a good bow and were really good at living off their horses), but they held more land than many modern societies for over a century.

And that probably is the trouble with a multi-galactic, or really even a galactic setting for that matter the more you start really thinking of it.  You make things advance logically from era to era (a galactic empire being more advanced than a interstellar one, a multi-galactic dominion being more advanced than a galactic empire and so on)...  But that's the thing here.  There's individual galaxies with more stars than the local group as a whole, and if limited to only the local group it may not be so incomprehensible, right?  After all, it's only a few trillion star systems.

Wouldn't the issue of advancement be circumvented by making a FTL that makes intergalactic travel "easy"?  I mean, if a warp drive is discovered and going to another galaxy is possible by the 22nd century, would everyone necessarily have to be post-singularity self-replicating energy blobs capable of shitting Technetium just because of that?

Well, I suppose if you believe in the singularity than yes, but like I mentioned in the OP i've found civilizations in imaginary sci-fi worlds that have humans using Gauss weapons millenniums into the future just fine.  

However the more I think about it the idea really falls apart when you consider than whole milky way galaxy "system" of Magellanic clouds, star populations in the galactic halo and some tiny dwarf galaxies nearby like Fornax can produce similar results.