Hey there! You should think about expanding the view of your RP in your fantasy universe and get a different perspective on it. Change the mechanics of a game - you can create an exploration game in the amazons, a hard-boiled noire detective story, a slice-of-life day in the Olympic village...

You could frame a cover-up of alien contact within the universe, and see how it reacts. The absurd will be humans, vampires and werewolves all watching the sky in awe as a space-craft descends, while all three are just fine with each other existing and standing right next to them.