Hmm... it naturally depends on the setting, but some form of former-human uploaded and enhanced is an interesting route to take. At what point do they stop being a human? Do they consider themseleves human longer than society, or vice versa? And what parts of humanity do they want to hold on to? Other times, it's time to strap on mirror shades and robot arms, and jack into cyberspace. Especially when it's hilariously 80s and wars are fought over 200mb chips, computing power beyond comprehension.