This sounds super interesting.
Some things that come to mind to help you perhaps either develop the idea or just put curious people like me more at ease:
-how do people contract these 'diseases' that cause them to become humanoid creatures?
-how many is a "healthy number" of players?
-how big is this continent and what sorts of landforms are found in different regions? What sorts of creatures/types of people hail from different regions?
-what is religion like? Varied, or mostly consistent? Do different races have different religions or are they inter-racial?

Also, if you'd take me, I was thinking of a sort of holier than thou character. Like, she'll be a little badass, but mostly just a pompous person that works poorly with others. Do you think that'd be too much of a monkey wrench in the whole thing or do you think that'd work? Because I have this image in my mind and I'm actually kind of excited about it.