Well, as a sandbox roleplay, each character is effectively allowed to do whatever they want to. That being said, the GMs will be coordinating as puppet-masters setting up events, conflicts, and various plot-lines that will interlock and unite some characters together. For example, let's say Deon is fighting a cage match. Kate is Deon's cousin, Cerberus is looking for Kate. Given the seedy nature of Deon's location, a drug bust or some other event could occur, thus a law-enforcement or more morally inclined character could end up in the same location and potentially interact with multiple characters involved. 

With involvement of the GMs and creativity of the writers involved, we're making this a sandbox with a plot!