[quote=@Silvan Haven]
I think it would mostly come down to what type of godslayer it is. Holy magic tends to be specifically [i]good[/i] oriented. Although theoretically you could have a holy user who had death oriented powers.

If they faced up against say, a disease godslayer I imagine that the holy user would have the advantage. If the elements were somewhat more in line I would think that the holy user would be at a pretty massive disadvantage.
[/quote]

There are many factors in this I guess...in the end just try your best and hope :lol

Although I stand by that Angel slayers would be the most effective against Manami, but there ain't any so not too much of a problem anyway. Depending on the slayer they might have a different advantage over her anyway (e.g. Jack is a wizard saint XD)