Ironically, only Amazing Spider-Man was entirely set in high school.  The original Spider-Man and Amazing Spider-Man 2 only had a short part where they were in high school (and ASM2 had it last shorter, too, if I recall correctly).

And for the ASM movies, I thought it was interesting to look into the past of Peter's parents.  It is just that they did not execute it as well as the should have.