[quote=@Dedonus]
If there was a "Civil War" story arc in this game (although I personally think that it is way too early to do that.  It would probably devolve into an emotionless hero vs. hero war instead of friends vs. friends), the most likely story line would probably involve STRIKE trying to get a handle on the metahuman community.  Sides probably would be Strike plus blackmailed heroes vs. heroes who were not blackmailed.  One problem is that I don't know how much dirt STRIKE has on all the heroes.
[/quote]

Ummm. I would suggest asking the Players actually and see who STRIKE is allowed to dig up dirt on and how much? All the players, as far as I know, are more story based and would likely love to pit Heroes against Heroes. In addition, don't forget the other organisations as well that STRIKE could have connects with if the Players owning them give permission. Not to mention, you might be able to get some of the Villains and Heroes to work together as well which would be fun to see their reactions/distaste at this while seeing if they will mess with each other. Nothing like temptation for a hero being so close yet so far to their most hated enemy. 

Also keep in mind the Lost Haven Police Department has been mentioned to have some tactics toward dealing with Meta humans and so does Gene Co, though neither are global. This might even start a meta human registration act in order to maintain order and control? That might be an interesting global event.