Now this isn't my RP, but my take on a WoD-styled game would be to take pretty much whatever inspiration you want from any of the gamelines, and present it as a more generic dark fantasy/horror setting.

The three main gamelines are just more generic in nWoD versus oWoD. Most of the secondary gamelines are more interesting in nWoD in my experience. The exception being Geist compared to Wraith, which are different enough to be difficult to compare. Both versions of Demon however are super different, and the latter is totally dependent on the God Machine Chronicle. I like to pretend Beast and anything that came out after it doesn't exist.

I'm also quite fond of the Genius and Leviathan fangames. I think they occupy fun places in the Universal Movie Monster mythos.