My point was more along the lines that chromosomes are [i]not[/i] what define sex. (As XY females [i]do[/i] have one of the chromosomal sets you described, but aren't the "expected" sex for that set.) Biological sex is determined by the structure of the, eh, "end product". (It's also debatable whether chromosomal abnormalities like XYY (male), X_ (Turing, female), XXY (male) are mutations in the strictest sense - also note how all of those generally end up with one of the two "main" sexes, rather than intersex/nondefined variants ... of those, XYY has practically no effect whatsoever, save for slightly greater average height.)