I probably won't even try to get in with the miserable amounts of experience i have, but i still wanna ask, sorry if i'm getting in the way.

Do all powers in here have to have an obvious easily-exploitable weakness? It makes it look like the world is somehow trying to be fair towards all who don't have a superpower by mercilessly balancing the stronger metahumans.

Also, what weakness would you give to a person whose power is, for example, adaptive regeneration? Like, whatever does not kill him makes him stronger and also partially immune to whatever he survived. So for example after being once debilitated by strong pain he would become numb to it and after getting shocked very hard he will grow insulated scales. Would you simply prohibit even having a power that has a potential to overcome weaknesses? Or is it just the Player Characters who are supposed to be the small fry amongst actually powerful metahumans?