[@olcharlieboi]

Well both yes and no.  They would affect him somewhat.  But not more than it would slow him down.  An Ogre could bat him away with its club and he would probably return more pissed off after shrugging it off. 

Gun wounds would heal quickly and bullets would fall out. 

Explosions would blow parts off that would take a longer time to regenerate from. 

If his body is destroyed,  it could the a while for him to return.