[@Dedonus] My idea for Eddie Brock is that the original origin happens to him. Spider-Man catches the real Sin Eater, while Eddie gets his job taken for catching the fake one. Except in this version, Eddie becomes a drunk as his wife leaves. He starts growing a hatred for Spider-Man. 

In drunken rage, Eddie finds his wife's new house and tries to bust in. A neighbor comes over to try to stop him, but Eddie, to enraged to know what he's doing, shoots the neighbor in the head and the police soon come and arrest Eddie for murder.

Eddie's now in jail, but gets picked by OsCorp for a project they are working on. OsCorp has made a symbiote, known was Venom that would be used for soldiers in battle, it was a black goo. Eddie was forced to be a volunteer, and they injected the symbiote into him. Eddie turns into Venom, and starts a rampage in the test facility. Imagine Wolverine's Weapon X massacre but without claws. The symbiote gave him abilities (He doesn't have the organic webs though, since the symbiote didn't copy that from Spidey, at least yet.)

Eddie escapes into the city, and only has one goal: Killing Spider-Man.

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I seriously cannot think of someone else, because I really actually don't want one of my main characters to be just a Spider-Man villain.

Ugh, this is so hard. Plus Ben is off the list of possible characters, because Rin practically told me that I can't be Ben, because she's being Ultimate universe's Spider-Woman.

And now thinking about it, I don't have the humor to be Deadpool, and you just can't be a serious Deadpool.

...

I seriously cannot think of anything. Crap.